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Strategies to Bypass Side Effects by Targeting Additional Receptors To overcome the side effects associated with targeting a single glucagon family receptor, researchers are exploring combination therapies and the possibility of simultaneously targeting other receptors within the glucagon family, such as GIP (Gastric Inhibitory Peptide) receptor to enhance insulin secretion while mitigating the GI side effects of GLP-1R activation alone and Glucagon receptor to reduce glucose production in the liver without exacerbating hyperglycemia

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Contact details: Masao Toyoda MD/PhD, Division of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan