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Yes, you can experience rapid weight loss with semaglutide GLP-1, especially in the early stages of treatment

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14.2 Weight Management Trial in Pediatric Patients Ages 12 and Older with Obesity SAXENDA was evaluated in a 56-week, double-blind, randomized, parallel group, placebo controlled multi-center trial in 251 pubertal pediatric patients aged 12 to 17 years, with BMI corresponding to 30 kg/m2 or greater for adults by international cut-off points1 and BMI of 95th percentile or greater for age and sex (NCT02918279)

Dev Comp Immunol 35(10):10981101

Then, the cells were incubated at 37C for 4 h, followed by replacement of the medium with 100 L DMSO (Aladdin, D103272)