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Eventually, these actin filaments formed by v3 integrin-RhoA-mDia signaling develop into stress fibers in mature FAs when RhoA/ROCK activity generated by 51 integrin drives the phosphorylation of myosin ( FIGURE 2 (B) Fibronectin in the ECM promotes cooperative signaling between 41 and 51 integrins that activates RhoA-mediated stress fiber formation
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