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Since the 1960s, the animal most used in testing the carcinogenicity of tobacco smoke has been the Syrian Golden Hamster due to its resistance to pulmonary infections and the infrequency with which it spontaneously develops pulmonary tumors

Besides lung cancer, tobacco addiction can increase the risk of other forms of cancers including those affecting bladder, blood, cervix, stomach, pancreas, liver, kidneys, larynx, esophagus, colon, just to name a few

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Different formulations may have a distinct impact on withdrawal symptoms or on the urge to smoke, but whether one formulation is more effective than another is open to debate