Glutathione exists in two states, the reduced, active form, GHS, and the oxidized, inactive form, GSSG
John Buse, Director of the Diabetes Care Center at the University of North Carolina and a principal investigator in GLP-1 outcomes trials, has noted in published commentary that "the antioxidant milieu in type 2 diabetes is genuinely impaired, but whether exogenous supplementation corrects the underlying defect or simply raises circulating levels without tissue impact remains unresolved." [9] That distinction shapes the practical advice: correcting a documented deficiency (measured low whole-blood glutathione in a patient with poorly controlled diabetes) is a different clinical decision from empirically adding glutathione to a well-controlled patient already benefiting from dulaglutide's own oxidative-stress effects
In light of the cutting-edge experiments and advances he is making in his lab, I was surprised that Sinclair also continues to study resveratrol
Physiological reviews, 89(4), 13791412
Retatrutide is a peptide-based weight loss medication for type 2 diabetes and obesity
