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[7] In 1952, to study the biological likelihood of cancer being linked to smoking, Wynder published an animal study in the US journal Cancer Research that found that tobacco tar was carcinogenic when applied to the skin of mice

Discussion This study shows clear evidence that light smoking measured at baseline predicted a higher mortality risk to women than to men for participants in the cotton workers cohort and that an elevated risk was evident for diseases of the circulatory system and the respiratory system, especially bronchitis, emphysema and other COPD

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Also similar to wine, pipe tobacco improves with age, making the tracking of a tobacco collection an important task

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