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In this study, the greater treatment persistence and comparable adherence of semaglutide QW versus these other GLP-1 RAs may be a result of the associated clinical benefits of semaglutide QW such as improved glycemic control and greater weight loss [21, 25]

Although the pill exposes the digestive tract to more semaglutide than the injection would, its local effects on the gut are minor, Anekwe explained

Rotating injection sites, as advised by your provider, can further minimize discomfort

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Shedding 510% of body weight often makes a measurable difference, and medications like semaglutide that support weight loss can amplify those benefits