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Similarly, the results from a population-based cohort study demonstrated the linkage between low-selenium levels in toenails with OA-associated pain and disease severity 26,27

Gerontology 49: 191195, 2003

Another circadian clock protein PER2 inhibits the expression of PAI-1 in a CLOCK/BMAL1-dependent manner as an important factor in the development of these metabolic diseases after the circadian clock system is dysregulated (Oishi et al., 2009)